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ChemicalBook CAS DataBase List Glufosinate-P
35597-44-5

Glufosinate-P synthesis

4synthesis methods
The commercial production of glufosinate-P typically begins with the microbial fermentation of Streptomyces species, which naturally produce bialaphos, a tripeptide that can be hydrolysed to yield glufosinate. The racemic mixture is then subjected to chiral resolution or asymmetric synthesis to isolate the L-isomer, which exhibits the desired herbicidal activity. This process may involve acidification, crystallisation, and purification steps to achieve high enantiomeric purity.
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Yield:35597-44-5 93%

Reaction Conditions:

with ammonia in methanol;water at -5 - 60; for 3.66667 h;Solvent;Temperature;Reagent/catalyst;

Steps:

1-6 Example 2

First, the glufosinate hydrochloride (1 mol) was added to 100 ml of water and 300 ml of methanol, and thetemperature was raised to 60 ° C to dissolve it, and the temperature was lowered to 30 ° C, and 18.7 g ofammonia gas was introduced; then, the mixture was stirred at room temperature for 20 minutes. The temperaturewas lowered to -5 ° C, stirred for 3 hours, and the precipitated crystals were filtered, washed with methanol anddried to obtain 185.1 g of purified glufosinate monohydrate crystals, yield 93%, purity 97.9%.

References:

CN109369713,2019,A Location in patent:Paragraph 0037-0048

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