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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 4-Chloro-7-azaindole
55052-28-3

4-Chloro-7-azaindole synthesis

7synthesis methods
Using 7-azaindole as the raw material, hydrogen peroxide was used to carry out N-oxidation reaction to generate N-oxide. In the reaction between POCl? and N-oxide, diisopropylethylamine (DIPEA) was added as a catalyst to increase the yield. After the reaction was completed, 4-Chloro-7-azaindole was obtained by alkalization treatment with a yield of up to 85.6%.
7-Azaindole

271-63-6
582 suppliers
$9.00/5g

4-Chloro-7-azaindole

55052-28-3
485 suppliers
$6.00/1g

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Yield:55052-28-3 85%

Reaction Conditions:

with 3-chloro-benzenecarboperoxoic acid;trichlorophosphate in 1,2-dimethoxyethane;n-heptane at 20 - 85; for 18 h;

Steps:

1 Preparation of 4-chloro-1-(triisopropylsilyl)-lH-pyrrolo [2,3-b]pyridine (1)

7-azaindole (3.6 g, 30 mmol) was dissolved in dimethoxyethane (17 ml) and heptane (33 ml), meta-chloroperoxybenzoic acid (mCPBA) (8.1 g, 77% And the mixture is stirred at room temperature. The mixture was filtered through a filter paper using a solution of dimethoxyethane (34 ml) and heptane (64 ml), phosphorus oxychloride (POCl3) (22 ml, 0.24 mol) was added to the obtained compound,For 18 hours The mixture is heated under reflux at 80°C . The mixture is sufficiently cooled, diluted with water (150 ml), and adjusted to pH 10 with 6N sodium hydroxide (NaOH). The mixture was filtered on a filter paper using water to obtain a solid compound (1) having a pale orange color. (3.9 g, 85% yield):

References:

KR101548492,2015,B1 Location in patent:Paragraph 0048; 0049

Benzoic acid, 3-chloro-, compd. with 7-hydroxy-7H-pyrrolo[2,3-b]pyridine (1:1)

74420-18-1
0 suppliers
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4-Chloro-7-azaindole

55052-28-3
485 suppliers
$6.00/1g

References
7-OXIDE-7-AZAINDOLE

55052-24-9
151 suppliers
$80.00/5G

4-Chloro-7-azaindole

55052-28-3
485 suppliers
$6.00/1g

References
Methanesulfonyl chloride

124-63-0
0 suppliers
$10.00/5g

7-OXIDE-7-AZAINDOLE

55052-24-9
151 suppliers
$80.00/5G

4-Chloro-7-azaindole

55052-28-3
485 suppliers
$6.00/1g

References
1H-Pyrrolo[2,3-b]pyridine, 4-chloro-1-(phenylsulfonyl)-

744209-63-0
82 suppliers
$45.00/10mg

4-Chloro-7-azaindole

55052-28-3
485 suppliers
$6.00/1g

References

4-Chloro-7-azaindole Related Search:

Clopidol Indometacin Indole-3-butyric acid Indole-3-acetic acid Pyridine 1-Benzylazetidin-3-ol Acetic acid, [(5-chloro-2-pyridinyl)aMino]oxo- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 6-Methoxyindole 7-Azabicyclo[2,2,1]heptane hydrochloride