4-Methylbenzamide oxime synthesis
- Product Name:4-Methylbenzamide oxime
- CAS Number:19227-13-5
- Molecular formula:C8H10N2O
- Molecular Weight:150.18
104-85-8
331 suppliers
$11.00/25g
121-44-8
891 suppliers
$9.00/5g
19227-13-5
107 suppliers
$10.00/250mg
Yield: 62%
Reaction Conditions:
with hydroxylamine hydrochloride in aqueous EtOH;ethanol
Steps:
2 2.1 Synthesis of p-Tolylamidoxime (2a)
2.1 Synthesis of p-Tolylamidoxime (2a) Hydroxylamine hydrochloride (1.3 g, 18 mmol) was added to a solution of Et3 N (2.5 mL, 18 mmol) in 50% aqueous EtOH (4.2 mL). After 30 minutes p-methylbenzonitrile (1.7 g, 15 mmol) in EtOH (40 mL) was added and the mixture was allowed to reflux for 8 hours. The mixture was cooled to room temperature and poured into water (100 mL). The aqueous solution was decanted, concentrated to half of its original volume. Upon standing the product crystallized to afford 2a as a white solid (1.7 g, 62 %); m/z (M+H)+ 150.2 (C8 H110 N2 O).
References:
CombiChem, Inc. US6107313, 2000, A
104-85-8
331 suppliers
$11.00/25g
19227-13-5
107 suppliers
$10.00/250mg
104-87-0
527 suppliers
$6.00/25g
19227-13-5
107 suppliers
$10.00/250mg
104-85-8
331 suppliers
$11.00/25g
75-05-8
1037 suppliers
$10.00/10g
19227-13-5
107 suppliers
$10.00/250mg
104-85-8
331 suppliers
$11.00/25g
19227-13-5
107 suppliers
$10.00/250mg
619-55-6
196 suppliers
$5.00/1g