1-[4,8-bis-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-yl]-2,2,2-trifluoroethanone, 1,4,8-tris(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane, 1,4,8-tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane, N,N',N''-tris(trifluoroace synthesis
- Product Name:1-[4,8-bis-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-yl]-2,2,2-trifluoroethanone, 1,4,8-tris(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane, 1,4,8-tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane, N,N',N''-tris(trifluoroace
- CAS Number:406939-92-2
- Molecular formula:C16H21F9N4O3
- Molecular Weight:488.35
295-37-4
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383-63-1
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$10.00/25g
406939-92-2
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$1055.00/1g
Yield:406939-92-2 95%
Reaction Conditions:
with triethylamine in methanol at 20; for 5.08333 h;
Steps:
1.A; 18
4.006 g (20 mmol) of cyclam (1,4,8,11-tetraazacyclotetradecane) was placed into a solution of 2.79 ml of triethylamine in 15 ml of dried methanol. 6.92 ml of ethyl trifluoroacetate was added dropwise to the upper solution at room temperature with stirring. The addition continued over a period of 5 min. The homogeneous reaction mixture was cooled with an ice-water bath to control the mild exothermicity. Stirring was continued under nitrogen for 5 hours. Volatiles were removed in vacuo. The residue was passed through a small silica-gel plug (25 g) and eluted with 100% ethyl acetate. The eluted solvent was concentrated to give the product as a white foam (8.972 g, 95% yield).
References:
US2007/248537,2007,A1 Location in patent:Page/Page column 37; sheet 21; sheet 22
295-37-4
300 suppliers
$18.00/250mg
76-05-1
668 suppliers
$9.00/1g
406939-92-2
18 suppliers
$1055.00/1g