4-Bromo-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid synthesis

2synthesis methods

Product Name:4-Bromo-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid
CAS Number:497833-05-3
Molecular formula:C6H4BrF3N2O2
Molecular Weight:273.01

1-Methyl-3-(trifluoromethyl)-1H-pyrazole

154471-65-5
138 suppliers
$14.00/1g

4-Bromo-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxylic acid

497833-05-3
22 suppliers
$328.00/100mg

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 65 percent / bromine; iron powder / 4 h / 100 °C
2: 90 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C

References:

Schlosser, Manfred;Volle, Jean-Noel;Leroux, Frederic;Schenk, Kurt [European Journal of Organic Chemistry,2002,# 17,p. 2913 - 2920]

124-38-9
721 suppliers
$214.00/14L

497832-99-2 Synthesis

4-Bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole

497832-99-2
102 suppliers
$16.00/100mg

497833-05-3
22 suppliers
$328.00/100mg

References

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