5-BROMO-2-HYDRAZINO-1H-1,3-BENZIMIDAZOLE synthesis
- Product Name:5-BROMO-2-HYDRAZINO-1H-1,3-BENZIMIDAZOLE
- CAS Number:54303-63-8
- Molecular formula:C7H7BrN4
- Molecular Weight:227.06
683240-76-8
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Yield:-
Reaction Conditions:
with hydrazine hydrate at 100;
Steps:
Typical experimental procedure for substituted 2-hydrazino-benzimidazol (3)
General procedure: A mixture of 2-chloro-5-methyl-benzimidazole (10.2 g, 61.2 mmol) and hydrazine monohydrate (59 mL, 1.22 mol) was stirred at 100 °C overnight. After being cooled to ambient temperature, to the reaction mixture was added to water (60 mL). After stirring under ice cooling, the resulting precipitates were collected by filtration. The precipitates were washed with water 3 times, and then dried in vacuo to give 2-hydrazino-5-methyl-benzimidazole (8.4 g, 84.6%).
References:
Nakao, Syuhei;Mabuchi, Miyuki;Shimizu, Tadashi;Itoh, Yoshihiro;Takeuchi, Yuko;Ueda, Masahiro;Mizuno, Hiroaki;Shigi, Naoko;Ohshio, Ikumi;Jinguji, Kentaro;Ueda, Yuko;Yamamoto, Masatatsu;Furukawa, Tatsuhiko;Aoki, Shunji;Tsujikawa, Kazutake;Tanaka, Akito [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 4,p. 1071 - 1074] Location in patent:supporting information
1575-37-7
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39513-26-3
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