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ChemicalBook CAS DataBase List (5-BROMO-PYRIDIN-3-YL)-ACETONITRILE
39891-08-2

(5-BROMO-PYRIDIN-3-YL)-ACETONITRILE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 20 °C
1.2: 12 h
2.1: thionyl chloride / dichloromethane / 2 h
3.1: N,N-dimethyl-formamide / 12 h / 20 °C

References:

Mukherjee, Paramita;Li, Huiying;Sevrioukova, Irina;Chreifi, Georges;Martsek, Pavel;Roman, Linda J.;Poulos, Thomas L.;Silverman, Richard B. [Journal of Medicinal Chemistry,2015,vol. 58,# 3,p. 1067 - 1088]

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