5-Ethyl-2-thiophenecarboxaldehyde synthesis
- Product Name:5-Ethyl-2-thiophenecarboxaldehyde
- CAS Number:36880-33-8
- Molecular formula:C7H8OS
- Molecular Weight:140.2
40323-88-4
86 suppliers
$20.20/1g
36880-33-8
113 suppliers
$10.00/250mg
Yield: 81%
Reaction Conditions:
with trichlorophosphate in N,N-dimethyl-formamide at 100; for 8 h;Cooling with ice;
Steps:
General procedure: To a stirred solution of 9ha-9hd (200 mmol) in dried DMF (43.86 g, 600 mmol) cooled in anice-water bath was added dropwise POCl3 (46.00 g, 300 mmol). The resulting mixture was stirred atthis temperature for 30 min and then at 100 °C for another 5 h. After cooling to room temperature,the reaction mixture was poured carefully into ice-water (300 mL). The mixture thus obtained wasextracted with CH2Cl2 (300 mL × 3), and the combined extracts were washed successively with 5%brine (200 mL), 10% aqueous K2CO3 (200 mL) and 5% brine (200 mL), dried (Na2SO4) and evaporatedon a rotary evaporator to afford a residue, which was purified by column chromatography to yield10ha-10hd.
References:
Cai, Wenqing;Wu, Jingwei;Liu, Wei;Xie, Yafei;Liu, Yuqiang;Zhang, Shuo;Xu, Weiren;Tang, Lida;Wang, Jianwu;Zhao, Guilong [Molecules,2018,vol. 23,# 2,art. no. 252]
15022-15-8
33 suppliers
$130.00/50mg
36880-33-8
113 suppliers
$10.00/250mg
872-55-9
174 suppliers
$22.00/5g
93-61-8
299 suppliers
$10.00/5 g
36880-33-8
113 suppliers
$10.00/250mg
872-55-9
174 suppliers
$22.00/5g
36880-33-8
113 suppliers
$10.00/250mg