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109954-64-5

5'-Tosyl-2'-deoxy Guanosine synthesis

1synthesis methods
Guanosine, 2′-deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-, 5′-(4-methylbenzenesulfonate)

1070789-72-8
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5'-Tosyl-2'-deoxy Guanosine

109954-64-5
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Yield:109954-64-5 70%

Reaction Conditions:

with hydrogen fluoride in water;acetonitrile at 20; for 24 h;

References:

Liang, Fengting;Jain, Nidhi;Hutchens, Troy;Shock, David D.;Beard, William A.;Wilson, Samuel H.;Chiarelli, M. Paul;Cho, Bongsup P. [Journal of Medicinal Chemistry,2008,vol. 51,# 20,p. 6460 - 6470] Location in patent:experimental part