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ChemicalBook CAS DataBase List 7-Hydroxy-1β,4aα-dimethyl-8-methylenegibbane-1α,10β-dicarboxylic acid
51576-08-0

7-Hydroxy-1β,4aα-dimethyl-8-methylenegibbane-1α,10β-dicarboxylic acid synthesis

2synthesis methods
Gibbane-1,10-dicarboxylic acid, 4a-formyl-7-(methoxymethoxy)-1-methyl-8-methylene-, (1α,4aα,4bβ,10β)-

144708-75-8
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7-Hydroxy-1β,4aα-dimethyl-8-methylenegibbane-1α,10β-dicarboxylic acid

51576-08-0
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) NH2-NH2 2.) NaOH / 1.) 1,2-ethanediol, 100 deg C, 30 min 2.) 1,2-ethanediol, 116 deg C, 1 h then 174 C, overnight
2: 71 percent / H2O, Dowex 50W-X2 resin H(1+) / methanol / 2 h / Heating

References:

Mander, Lewis N.;Owen, David J.;Twitchin, Bruce [Australian Journal of Chemistry,1996,vol. 49,# 2,p. 249 - 253]

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