methyl 2-(methylamino)cyclopent-1-ene-1-carboxylate synthesis

Yield:52909-71-4 82%

Reaction Conditions:

with silica gel in tetrahydrofuran at 20;

Steps:

Typical Experimental Procedure.

General procedure: To a mixture of 1 (621 μL, 0.711 g, 5 mmol) and SiO₂ (7.11 g, 10 g per 1 g of 1), was added corresponding amines 2a-z (1.0 equiv) dropwise while stirring at rt. The resulting solid mixture was typically stirred for 1 h to overnight at rt. Upon complete consumption of starting material based on LCMS analysis, the solid mixture was purified by silica gel column chromatography to give the desired products 3a-z upon drying under vacuum (Table 1).

References:

Kim, Soong-Hyun;Bae, Seri;Ko, Eun Bi;Park, Ga Young;Lee, Eunhye;Hwang, Hee Jong;Im, Chun Young;Song, Minsoo [Bulletin of the Korean Chemical Society,2019,vol. 40,# 3,p. 262 - 269]