6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester synthesis
- Product Name:6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetate,methyl ester
- CAS Number:55689-64-0
- Molecular formula:C17H14O4
- Molecular Weight:282.29
67-56-1
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Yield:55689-64-0 96%
Reaction Conditions:
with tert.-butylnitrite at 40; for 48 h;
Steps:
14
Add drug molecule 1n (Isoxepac) (0.5 mmol, 134.2mg) and methanol containing 40mol% tert-butyl nitrite to the reaction test tube; then react for 48 hours at 40°C in air; after the reaction, add sulfur Sodium sulphate is stirred and quenched, the solvent is removed with a rotary evaporator, the silica gel is adsorbed, and finally the product 3n is obtained by column chromatography with a mixed solvent of ethyl acetate and petroleum ether, with a yield of 96%.
References:
CN112552171, 2021, A Location in patent:Paragraph 0036-0037
55453-87-7
352 suppliers
$5.00/25mg
55689-64-0
67 suppliers
inquiry