1-(4-fluorophenyl)-1H-1,2,3-triazole-4-carbaldehyde synthesis
- Product Name:1-(4-fluorophenyl)-1H-1,2,3-triazole-4-carbaldehyde
- CAS Number:578703-90-9
- Molecular formula:C9H6FN3O
- Molecular Weight:191.16
1225046-93-4
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578703-90-9
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Yield:578703-90-9 79%
Reaction Conditions:
with Jones reagent in acetone at 0; for 0.583333 h;
Steps:
Preparation of 1- substituted-(1,2,3)triazol-4-carbaldehyde (3)
General procedure: 1-substituted-(1,2,3)triazol-4-yl-methanol 2 ( 4 mmol) was taken in dry acetone and cool to 0 0C and added the Jones reagent (CrO3+H2SO4+Acetone) (4 mmol) slowly over 15 mins. The reaction mixture was stirred for 20 mins at 0 0C. After completion of reaction, the reaction mixture was filtered through the short pad of celite and collected the filtrate, and concentrated under vaccum. The residue was purified by passing through a column packed with silica gel using petroleum ether/EtOAc (8:2) as eluents.
References:
Sambasiva Rao;Kurumurthy;Veeraswamy;Santhosh Kumar;Shanthan Rao;Pamanji;Venkateswara Rao;Narsaiah [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 5,p. 1225 - 1227] Location in patent:supporting information
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578703-90-9
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3296-02-4
11 suppliers
$220.00/500mg
578703-90-9
10 suppliers
inquiry