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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 6-Methylnicotinic acid
3222-47-7

6-Methylnicotinic acid synthesis

11synthesis methods
6-Methylnicotinic acid is prepared by selective oxidation of 2-methyl-5-alkylpyridine, wherein the alkyl group has 2 to 8 carbon atoms, using nitric acid at a concentration of 70 to 100 weight percent HNO3, wherein 6 to 15 moles of NHO3 are used per mole of pyridine, and the reaction is carried out at a temperature range of 250 to 325*F. The reaction time is 10 to 60 minutes, and superatmospheric pressure is used to effectively maintain the reactants in the liquid phase, and 6-methylnicotinic acid is recovered from the resulting reaction mixture.
5470-70-2 Synthesis
Methyl 6-methylnicotinate

5470-70-2
539 suppliers
$5.00/5g

6-Methylnicotinic acid

3222-47-7
357 suppliers
$6.00/1g

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Yield:3222-47-7 100%

Steps:

96.a a)
a) 6-methylnicotinic Acid Following the procedure of Example 1(g), except substituting methyl-6-methylnicotinate for N-(4-pyridinylmethoxycarbonyl)-L-leucine methyl ester, the title compound was prepared as a white solid (506 mg, 100%). MS (ESI): 137.9 (M+H)+.

References:

Halbert, Stacie Marie;Michaud, Evelyne;Thompson, Scott Kevin;Veber, Daniel Frank US2002/49316, 2002, A1

FullText

140-76-1 Synthesis
2-Methyl-5-vinylpyridine

140-76-1
149 suppliers
$21.00/250mg

6-Methylnicotinic acid

3222-47-7
357 suppliers
$6.00/1g

References
21684-59-3 Synthesis
ETHYL 6-METHYLPYRIDINE-3-CARBOXYLATE

21684-59-3
105 suppliers
$17.00/1g

6-Methylnicotinic acid

3222-47-7
357 suppliers
$6.00/1g

References
104-90-5 Synthesis
5-Ethyl-2-methylpyridine

104-90-5
269 suppliers
$14.00/5mL

6-Methylnicotinic acid

3222-47-7
357 suppliers
$6.00/1g

5-ETHYLPYRIDINE-2-CARBOXYLIC ACID

770-08-1
92 suppliers
$140.00/1g

100-26-5 Synthesis
2,5-PYRIDINEDICARBOXYLIC ACID

100-26-5
369 suppliers
$8.00/5g

References
589-93-5 Synthesis
2,5-Dimethylpyridine

589-93-5
139 suppliers
$32.00/5mL

5-METHYLPICOLINIC ACID

4434-13-3
141 suppliers
$21.00/250mg

6-Methylnicotinic acid

3222-47-7
357 suppliers
$6.00/1g

100-26-5 Synthesis
2,5-PYRIDINEDICARBOXYLIC ACID

100-26-5
369 suppliers
$8.00/5g

References

6-Methylnicotinic acid Related Search:

Methyl 6-methylnicotinate 2,5-PYRIDINEDICARBOXYLIC ACID N,N-Dimethylpropionamide 2-Phenylbutyric acid 1-(6-Methylpyridin-3-yl)-2-(4-(Methylthio)phenyl)ethanone 3,5-Dichloropyridine 4-Methylsulphonylphenylacetic acid 1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone Methyl nicotinate Isonicotinic acid