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ChemicalBook CAS DataBase List 2-Bromo-8-chloro-4-(trifluoromethyl)quinoline-3-carboxylic acid
663193-41-7

2-Bromo-8-chloro-4-(trifluoromethyl)quinoline-3-carboxylic acid synthesis

4synthesis methods
-

Yield:663193-41-7 78%

Reaction Conditions:

Stage #1: 2-bromo-8-chloro-4-(trifluoromethyl)quinolinewith n-butyllithium;diisopropylamine in tetrahydrofuran;hexane at -75; for 2 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane at -78;

References:

Marull, Marc;Lefebvre, Olivier;Schlosser, Manfred [European Journal of Organic Chemistry,2004,# 1,p. 54 - 63]