4,6-dimethyl-2-phenacylsulfanylpyridine-3-carbonitrile synthesis
- Product Name:4,6-dimethyl-2-phenacylsulfanylpyridine-3-carbonitrile
- CAS Number:72456-88-3
- Molecular formula:C16H14N2OS
- Molecular Weight:282.36
54585-47-6
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Yield:72456-88-3 78%
Reaction Conditions:
with potassium hydroxide in water;N,N-dimethyl-formamide; for 4 h;
Steps:
Alkylation of compound 4
General procedure: To a mixture of 1.64 g (10 mmol) of compound 4 and 15 mL of DMF we added under stirring in succession 5.6 mL (10 mmol) of 10% aqueous KOH and 10 mmol of alkylating agent 5a-5n or 7. The mixture was stirred for 4 h and diluted with an equal volume of water, and the precipitate of 6a-6n or 8 was filtered off, and washed with water, ethanol, and hexane.
References:
Dyachenko;Dyachenko [Russian Journal of Organic Chemistry,2016,vol. 52,# 1,p. 32 - 36][Zh. Org. Khim.,2016,vol. 52,# 1,p. 40 - 43]
