7-bromo-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride synthesis
- Product Name:7-bromo-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride
- CAS Number:740842-72-2
- Molecular formula:C9H11BrClNO
- Molecular Weight:264.55
740842-73-3
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$100.00/1g
740842-72-2
21 suppliers
$519.00/500mg
Yield:740842-72-2 98%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;ethanol at 20; for 1 h;Heating;
Steps:
4.1
l,l-dimethylethyl 7-bromo-2,3-dihydro-l,4-benzoxazepine-4(5H)- carboxylate (reagent preparation 21) (10 g, 30.5 mmol) was taken into hot ethanol (10 mL) followed by addition of 4M hydrogen chloride in dioxane solution (2.1 eq, 16 mL) and the resulting solution was allowed to slowly cool to ambient temperature over one hour. An excess of ethyl ether was then added and the resulting slurry was filtered. The filter cake was washed with ethyl ether and dried to give 7-bromo-2,3,4,5-tetrahydro-l,4-benzoxazepine hydrochloride (7.9 g, 98% yield) as a colorless crystalline solid. MS (EI) for C9Hi0NOBr: 229 (MH+).
References:
WO2010/138490,2010,A1 Location in patent:Page/Page column 56
5755-05-5
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740842-72-2
21 suppliers
$519.00/500mg
58430-20-9
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740842-72-2
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$519.00/500mg
6329-74-4
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$6.00/1g
740842-72-2
21 suppliers
$519.00/500mg
1761-61-1
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$5.00/5g
740842-72-2
21 suppliers
$519.00/500mg