5-Bromo-4-(trifluoromethyl)thiazol-2-amine hydrobromide synthesis

Yield:79247-81-7 90%

Reaction Conditions:

with bromine in diethyl ether at 0; for 1 h;

Steps:

22

Preparation 225-Bromo-4-trifluoromethyl-thiazol-2-ylamine, hydrobromide Add bromine (2.0 mL, 6.28 g, 39.3 mmol) dropwise to an ice-bath cooled solution of 4-trifluoromethyl-thiazole-2-ylamine (6.0 g, 35.7 mmol) in diethyl ether (60 mL). Stir for one hour after the addition is complete and then warm to room temperature. Collect the solids by filtration and wash with diethyl ether to obtain the title compound (10.5 g, 90%). ES/MS m/z (⁷⁹Br/⁸¹Br) 247/249 (M+ 1)⁺.

References:

WO2008/36579,2008,A1 Location in patent:Page/Page column 43-44