methyl 2-(2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetate synthesis

2synthesis methods

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 88 percent / HOBt; TBTU; EtN(i-Pr)2 / acetonitrile / 4 h / 20 °C
2: 79 percent / NaOH / methanol / 0.5 h

References:

Philipova, Irena;Linden, Anthony;Heimgartner, Heinz [Helvetica Chimica Acta,2005,vol. 88,# 7,p. 1711 - 1733]

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