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ChemicalBook CAS DataBase List 5-Fluoro-1,2,3,4-tetrahydro-naphthalen-1-ylamine hydrochloride
907973-43-7

5-Fluoro-1,2,3,4-tetrahydro-naphthalen-1-ylamine hydrochloride synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 °C
1.2: 0 - 20 °C
2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 18 h / Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol

References:

US2008/119496,2008,A1