Carboxin synthesis

12synthesis methods

Product Name:Carboxin
CAS Number:5234-68-4
Molecular formula:C12H13NO2S
Molecular Weight:235.3

Carboxin is synthesised through a multi-step chemical process that begins with ethyl 2-chloroacetoacetate reacting with 2-mercaptoethanol in the presence of a base. This forms a key intermediate that undergoes cyclization and dehydration under acidic conditions to yield the 1,4-oxathiine heterocycle. The resulting ethyl ester is then converted into a carboxylic acid, which is subsequently transformed into an acid chloride. This intermediate is reacted with aniline under standard amidation conditions to produce carboxin in high yield.

1,3-Oxathiolane-2-acetamide, 2-methyl-N-phenyl-

67980-06-7
0 suppliers
inquiry

5234-68-4
253 suppliers
$10.00/1g

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 0.4968 g / 35percent aq. H₂O₂, acetic acid / 1 h / 15 - 20 °C
2: 1.) p-toluenesulfonic acid (PTSA), 2.) PTSA / 1.) C₆H₆, DMF, 50 deg C, 24 h, 2.) C₆H₆, reflux, 2.5 h

References:

Wha Suk Lee;Hoh Gyu Hahn. Kee Dal Nam [Journal of Organic Chemistry,1986,vol. 51,# 14,p. 2789 - 2795]

1,3-Oxathiolane-2-acetamide, α-hydroxy-2-methyl-N-phenyl-

180068-90-0
0 suppliers
inquiry

69892-02-0 Synthesis

5,6-DIHYDRO-3-METHYL-N-PHENYL-1,4-OXATHIN-2-CARBOXAMIDE

69892-02-0
15 suppliers
inquiry

5234-68-4
253 suppliers
$10.00/1g

References

2-Butenamide, 3-chloro-2-[(2-hydroxyethyl)thio]-N-phenyl-, (2Z)-

1048972-92-4
0 suppliers
inquiry

5234-68-4
253 suppliers
$10.00/1g

References

102-01-2 Synthesis

102-01-2
0 suppliers
$5.00/100g

5234-68-4
253 suppliers
$10.00/1g

References

2-Butenamide, 3,3'-[dithiobis(2,1-ethanediyloxy)]bis[N-phenyl- (9CI)

102437-91-2
0 suppliers
inquiry

5234-68-4
253 suppliers
$10.00/1g

References

Carboxin Related Search:

2-[(2-AMINOETHYL)THIO]ETHAN-1-OL

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.