CEFATHIAMIDINE synthesis
- Product Name:CEFATHIAMIDINE
- CAS Number:33075-00-2
- Molecular formula:C19H28N4O6S2
- Molecular Weight:472.58
Yield:33075-00-2 92.2%
Reaction Conditions:
with N,N-dimethyl-formamide in dichloromethane at 20; for 2 h;
Steps:
5; 6; 7; 8 Example 6 Preparation of Cefotaxime
In a 250 ml reaction bottle, add 100 mL of dichloromethane and 10.44 g of the chloroacetyl 7-ACA obtained in Example 1.3.29g N, N-dimethylformamide,While stirring, add 5.28g of N, N-diisopropylthiourea, and stir at room temperature for 2h.The reaction was complete by HPLC.The reaction solution was concentrated under reduced pressure at 35C until no obvious liquid flowed down.Add 90mL of absolute ethanol,Heat to 40 ~ 50C and stir to dissolve,After dissolving, cool down to 0 ~ 10 ° C,There is solid precipitation,Continue stirring for 2h.Suction filtration,Washing with absolute ethanol,40C vacuum drying for 4h,13.06g of cefathiamidine was obtained.Yield 92.2%,Purity 99.9%,The maximum single impurity is 0.06%, and the moisture is 0.07%.
References:
Shandong Luoxin Pharmaceutical Group Co., Ltd.;Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.;Shandong Yuxin Pharmaceutical Co., Ltd.;Li Minghua;Xie Youcui;Sui Tao CN110407857, 2019, A Location in patent:Paragraph 0045-0052; 0059-0064
26973-80-8
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33075-00-2
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$50.00/10mg