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ChemicalBook CAS DataBase List Chlorpropham
101-21-3

Chlorpropham synthesis

6synthesis methods
Chlorpropham is produced commercially through a reaction between 3-chlorophenyl isocyanate and isopropanol. The synthesis begins with the preparation of 3-chlorophenyl isocyanate, a key intermediate, which is then reacted with isopropanol in the presence of a suitable catalyst or under controlled conditions to form chlorpropham. This reaction is typically carried out in an organic solvent to ensure high yield and purity.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 0 °C
1.2: 0.17 h
2.1: palladium dichloride; triethylamine / N,N-dimethyl acetamide / 24 h / 70 °C / 760.05 Torr / Schlenk technique

References:

Ren, Long;Jiao, Ning [Chemical Communications,2014,vol. 50,# 28,p. 3706 - 3709]

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