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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Diazinon
333-41-5

Diazinon synthesis

1synthesis methods
Commercial production of diazinon involves a carefully controlled multi-step synthesis to ensure high purity and minimal toxic by-products. The process typically begins with the reaction of 2-isopropyl-4-methyl-6-hydroxypyrimidine with a strong base like sodium or potassium hydroxide in a solvent such as a ketone or ether, maintained at around 50–60 DegC to form a homogeneous mixture. Next, diethylthiophosphoryl chloride is added, and the reaction mixture is kept at 55–80 DegC until the transformation is complete.
Diethyl chlorothiophosphate

2524-04-1
0 suppliers
$16.80/25G

2-Isopropyl-6-methyl-4-pyrimidinol

2814-20-2
145 suppliers
$13.00/10g

Diazinon

333-41-5
261 suppliers
$25.00/100mg

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Yield:333-41-5 50%

Reaction Conditions:

Stage #1:2-isopropyl-6-methyl-4-pyrimidinol with potassium hydroxide in ethanol
Stage #2:diethyl phosphorochloridothioate in acetone for 48 h;Heating;Further stages.;

References:

Churchill, Doreen;Dust, Julian M.;Buncel, Erwin [Canadian Journal of Chemistry,2007,vol. 85,# 6,p. 421 - 431]

FullText

Diazinon Related Search:

Diethyl phthalate N,N-Diisopropylethylamine Triethyl phosphate Methylparaben Clindamycin phosphate Isopropyl alcohol Trimethyl thiophosphate 2-Methylpyrimidine n-Nonane 2,4-Dimethyl-6-hydroxypyrimidine