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ChemicalBook CAS DataBase List DIMEFOX
115-26-4

DIMEFOX synthesis

10synthesis methods
The commercial production of dimefox begins with the reaction of phosphorus oxychloride with dimethylamine in a controlled solvent system, followed by fluorination using a fluoride source such as potassium fluoride. The reaction is conducted under precise temperature and pH conditions to optimize yield and minimize byproducts. The resulting crude dimefox is purified through distillation or solvent extraction to achieve high purity and formulated.
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Yield: 81%

Reaction Conditions:

with Amberlyst(R) A-26 resin in tetrahydrofuran at 20; for 2.5 h;

References:

Sierakowski, Timothy;Kiddle, James J. [Tetrahedron Letters,2005,vol. 46,# 13,p. 2215 - 2217]