ethyl 3,3-diphenylacrylate synthesis
- Product Name:ethyl 3,3-diphenylacrylate
- CAS Number:17792-17-5
- Molecular formula:C17H16O2
- Molecular Weight:252.31
Yield:17792-17-5 95%
Reaction Conditions:
with dipalladium(II)(1,1'-di-t-butyl-3,3'-(1,2-ethanediyl)bisimidazolium)dipyridinetetradichloride;tetrabutylammomium bromide;sodium acetate in N,N-dimethyl acetamide at 120; for 18 h;Inert atmosphere;Heck Reaction;
Steps:
1 4.3. Representative procedure for β,β-diarylation of terminal olefins
General procedure: To a stirred solution of TBAB (1 mmol, 322 mg), sodium acetate (102 mg, 1.25 mmol), and catalyst (4 mg, 0.005 mmol) in DMA (2 mL) was added aryl halide (1.1 mmol) and olefin (0.5 mmol). The mixture was stirred at 120 °C for 18 h under argon. The solids were removed by filtration, and rinsed with 10mL of ethyl acetate. The filtrate was concentrated under vacuum. The crude product was purified by flash column chromatography using petroleum ether (PE) and ethyl acetate (EA) as the eluent (PE/EA 30/1).
References:
Li, Yunfei;Liu, Gang;Cao, Changsheng;Wang, Shuzhan;Li, Yuling;Pang, Guangsheng;Shi, Yanhui [Tetrahedron,2013,vol. 69,# 30,p. 6241 - 6250]
