ChemicalBook CAS DataBase List FUBERIDAZOLE

FUBERIDAZOLE synthesis

12synthesis methods

Product Name:FUBERIDAZOLE
CAS Number:3878-19-1
Molecular formula:C11H8N2O
Molecular Weight:184.19

Fuberidazole is commercially produced through a two-step synthesis involving o-phenylenediamine and furfural. Production begins with the condensation of ortho-phenylenediamine and furfural in aqueous solution. This reaction is typically catalysed by sodium hydrogen sulphite and carried out under reflux conditions to promote cyclization and formation of the benzimidazole ring. The resulting product, 2-(furan-2-yl)-1H-benzimidazole, precipitates upon cooling and is collected by vacuum filtration. The crude solid is washed with water and dried under vacuum to yield high-purity fuberidazole.

98-01-1 Synthesis

98-01-1
520 suppliers
$19.70/250g

95-54-5 Synthesis

95-54-5
542 suppliers
$9.00/1g

3878-19-1
114 suppliers
$44.00/1g

Yield:3878-19-1 99%

Reaction Conditions:

with sodium hydrogensulfite in waterReflux;

Steps:

2.2.1. General procedure for the synthesis of 2-substituted benzimidazoles[47]
General procedure: A mixture of aldehyde (10.00 mmol) and NaHSO3 (11.0 equiv.,11.45 g) in H2O (30 mL) was heated to refilux. A solution of an o-phenylenediaminederivative (10.00 mmol) in H2O (10 mL) was addeddropwise to the solution and the reaction was further refluxed. Uponcompletion, the reaction mixture was cooled to room temperature andthe precipitate was collected by vacuum filtration. The residue waswashed with H2O and dried under vacuum.

References:

Han, Min Su;Jung, Minhyuk;Kim, Jaewon;Kim, Sudeok;Lee, Hohjai;Lee, Suji [Dyes and Pigments,2020,vol. 177]

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617-89-0 Synthesis