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ChemicalBook CAS DataBase List gamma-Linolenic acid
506-26-3

gamma-Linolenic acid synthesis

12synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 7 steps
1: ammonia
2: acid
3: 89 percent / K2CO3, NaI, CuI / dimethylformamide / 12 h
4: 92 percent / CBr4, PPh3 / CH2Cl2 / 1 h / Ambient temperature
5: 89 percent / K2CO3, NaI, CuI / dimethylformamide / 40 °C
6: 65 percent / H2, (CH2NH2)2 / P-2 Ni / ethanol
7: 98 percent / LiOH, H2O / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) r.t., 12 h

References:

Durand, Sandrine;Parrain, Jean-Luc;Santelli, Maurice [Synthesis,1998,# 7,p. 1015 - 1018]

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