Gliclazide synthesis
- Product Name:Gliclazide
- CAS Number:21187-98-4
- Molecular formula:C15H21N3O3S
- Molecular Weight:323.41
![3-Amino-3-azabicyclo[3.3.0]octane hydrochloride](/CAS/GIF/58108-05-7.gif)
58108-05-7
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1694-06-0
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21187-98-4
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Yield:21187-98-4 86%
Reaction Conditions:
in toluene; for 3 h;Reflux;
Steps:
7 Example 7Preparation of gliclazide
To a 250 mL three-necked flask was added N-amino-3-azabicyclo [3.3.0] octane hydrochloride prepared in Example 6 (2)20 g of p-toluenesulfonylurea, 100 ml of toluene and heated under reflux for 3 hours. After the completion of the reaction,The toluene was distilled off under reduced pressure, 100 ml of water was added, and the crystals were stirred at room temperature for 12 hours. The solid was filtered,Recrystallization from ethyl acetate and drying under vacuum at 80 ° C for 15 h gave 37 g of product, yield 86%.
References:
CN106588746,2017,A Location in patent:Paragraph 0105; 0106; 0107; 0108
4083-64-1
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![3-Amino-3-azabicyclo[3.3.0]octane](/CAS/GIF/54528-00-6.gif)
54528-00-6
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21187-98-4
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120-92-3
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21187-98-4
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