HEXYLCROTONATE synthesis

Yield:1617-25-0 89%

Reaction Conditions:

with 2,2,6,6-tetramethylpiperidinium triflate in neat liquid at 120; for 24 h;Green chemistry;

Steps:

a. General experimental procedure for esterification

General procedure: Place carboxylic acid (2.0 mmol), alcohol (2.2 mmol), 5 mol% ( 0.1 mmol) of catalyst into a round-bottom flask containing a teflon-coated magnetic stir bar, then stir the system at 120 °C under solvent-free condition (Scheme 1). Trace thereaction by GC or ¹H NMR analysis. When the catalyst precipitated completely from the reaction medium at the end of the reaction, separated it by centrifugation, then washed it three times with petroleum ether. The pure ester was obtained by the column chromatography, indentified by ¹H NMR and ¹³C NMR analysis.

References:

Gao, Lan;Liu, Taoping;Tao, Xiaochun;Huang, Yongmin [Tetrahedron Letters,2016,vol. 57,# 44,p. 4905 - 4909] Location in patent:supporting information