L-Acetylcarnitine synthesis
- Product Name:L-Acetylcarnitine
- CAS Number:3040-38-8
- Molecular formula:C9H17NO4
- Molecular Weight:203.24
541-15-1
1002 suppliers
$5.00/5g
75-36-5
579 suppliers
$17.92/100G
3040-38-8
48 suppliers
$638.98/1G
Yield:3040-38-8 71.4%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 5; for 12 h;Concentration;
Steps:
1 Example 1
Equipped with a mechanical stirrer and thermometer, a three-necked flask was filled with 100 g of L-carnitine zwitterion (0.62 mol, 1 eq), dichloromethane 3 liters, and 188.2 g of triethylamine (1.86 mol, 3.0 eq). Stirring down to 0 ~ 5°C. 97.34 g of acetyl chloride (1.24 mol, 2.0 eq) was added dropwise. After dropping, the reaction was carried out at 0 to 5°C for 12 hours then filtered. The filter cake was washed with dichloromethane to obtain crude acetyl-L-carnitine. This was dissolved in an appropriate amount of ethanol. Stirring dissolved. The solid was then precipitated by the addition of acetone and filtered. The filter cake was washed with acetone. Vacuum drying to obtain refined products 90 grams, yield 71.4%, purity 99.6%. Nuclear magnetic resonance spectrum shown in Figure 1. The mass spectrum is shown in Figure 2.
References:
Guangdong Longfu Pharmaceutical Co. Ltd.;Zhang, Longxin;Zhang, Shengbin;Ou, Guanlin CN105732407, 2016, A Location in patent:Paragraph 0008; 0009
5080-50-2
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3040-38-8
48 suppliers
$638.98/1G
6645-46-1
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75-36-5
579 suppliers
$17.92/100G
3040-38-8
48 suppliers
$638.98/1G
108-24-7
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$14.00/250ML
541-15-1
1002 suppliers
$5.00/5g
3040-38-8
48 suppliers
$638.98/1G
6645-46-1
264 suppliers
$9.00/10g
3040-38-8
48 suppliers
$638.98/1G