
METHYL 2-PHENOXYPROPANOATE synthesis
- Product Name:METHYL 2-PHENOXYPROPANOATE
- CAS Number:2065-24-9
- Molecular formula:C10H12O3
- Molecular Weight:180.2
Yield:2065-24-9 186.66 g
Reaction Conditions:
Stage #1: phenolwith sodium hydrogencarbonate in toluene;Reflux;
Stage #2: 2-chloro-propionic acid methyl ester in toluene at 80; for 0.5 h;
Steps:
3.1; 4.1
To 95.06 g of 99% pure phenol,91.65 g of 99% pure sodium hydrogencarbonate and 427.77 g of toluene were added, and the mixture was refluxed and dehydrated to a water content of ≤0.5%, and 133.70 g of 99% pure methyl 2-chloropropionate was added dropwise thereto at 80 ° C to cause a reaction. After the addition is completed, the reaction is kept at this temperature for 0.5 h, the temperature is lowered to 50 ° C, filtered, and an appropriate amount of toluene is added to wash the filter cake.After drying, sodium chloride and crude 2-phenoxypropionate containing toluene are dried.Toluene was recovered by distillation, and 186.66 g of methyl 2-phenoxypropionate was obtained in an amount of 96.0%.
References:
CN108947814,2018,A Location in patent:Paragraph 0086; 0087; 0090; 0091