Methyl levulinate synthesis
- Product Name:Methyl levulinate
- CAS Number:624-45-3
- Molecular formula:C6H10O3
- Molecular Weight:130.14
Yield:624-45-3 99%
Reaction Conditions:
with sulfuric acid at 50; for 5 h;
Steps:
Methyl 4-oxopentanoate (2a)
General procedure: Sulfuric acid (0.1 ml) was added to a solution of levulinic acid (0.782 g, 7.0 mmol) in methanol (10 ml) and the mixture was heated at 50° C for 5 hours. The solution was evaporated under reduced pressure, and the residue was partitioned between saturated aqueous solution of NaHCO3 and ethyl acetate. The organic layer was separated, extracted with brine solution and dried over anhydrous MgSO4. Evaporation under reduced pressure afforded compound 2a (0.901 g, 99%). 1H NMR (400 MHz, CDCl3) δ 3.68 (3H, s, -OCH3), 2.76 (2H, t, J = 6.4 Hz, H-2), 2.58 (2H, t, J = 6.4 Hz, H-3), 2.20 (3H, s, -CH3).
References:
Seo, Jeong Moo;Hassan, Ahmed H.E.;Lee, Yong Sup [Tetrahedron,2019,vol. 75,# 51,art. no. 130760] Location in patent:supporting information
