N-P-TOLYL-GUANIDINE HYDROCHLORIDE synthesis
- Product Name:N-P-TOLYL-GUANIDINE HYDROCHLORIDE
- CAS Number:6976-07-4
- Molecular formula:C8H12ClN3
- Molecular Weight:0
![Carbamic acid, N,N'-[(4-methylphenyl)carbonimidoyl]bis-, C,C'-bis(1,1-dimethylethyl) ester](/CAS/20240320/GIF/1029802-07-0.gif)
1029802-07-0
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6976-07-4
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Yield:6976-07-4 98%
Reaction Conditions:
Stage #1: 1-[2,3-di(tert-butoxycarbonyl)guanidino]-4-methylbenzenewith trifluoroacetic acid in dichloromethane; for 3 h;
Stage #2: in water; for 24 h;
References:
Rodriguez, Fernando;Rozas, Isabel;Ortega, Jorge E.;Erdozain, Amaia M.;Meana, J. Javier;Callado, Luis F. [Journal of Medicinal Chemistry,2008,vol. 51,# 11,p. 3304 - 3312] Location in patent:supporting information; experimental part