ChemicalBook CAS DataBase List NIPRADILOL

NIPRADILOL synthesis

8synthesis methods

Product Name:NIPRADILOL
CAS Number:81486-22-8
Molecular formula:C15H22N2O6
Molecular Weight:326.35

91520-01-3 Synthesis

3,4-Dihydro-8-methoxy-2H-1-benzopyran-3-ol

91520-01-3
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81486-22-8
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 88.9 percent / 47 percent HBr / 9 h / 90 °C
2: 1.) ethyl chloroformate, triethylamine; 2.) Ac₂O, fum. HNO₃; 3.) NaOH / 1.) THF, 0-5 deg C, 0.5 h; 2.) acetonitrile, -8 deg C, 1 h; 3.) MeOH, H₂O, RT, 0.5 h
3: 1 N NaOH / 2 h / 50 °C
4: methanol / 1 h / 70 °C

References:

Shiratsuchi;Kawamura;Akashi;Fujii;Ishihama;Uchida [Chemical and Pharmaceutical Bulletin,1987,vol. 35,# 2,p. 632 - 641]

Phenol, 2-methoxy-6-(2-propenyl)-, acetate

2173-78-6
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81486-22-8
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References

acetic acid (8-methoxy-3,4-dihydro-2H-1-benzopyran-3-yl) ester

91520-04-6
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81486-22-8
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References

acetic acid [2-methoxy-6-(2-oxiranylmethyl)phenyl] ester

91520-02-4
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81486-22-8
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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81486-22-8
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References

NIPRADILOL Related Search:

toliprolol 1-AMINO-3-(2-METHOXY-PHENOXY)-PROPAN-2-OL

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