NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE synthesis
- Product Name:NZ-419,5-HYDROXY-1-METHYLIMIDAZOLIDINE-2,4-DIONE
- CAS Number:84210-26-4
- Molecular formula:C4H6N2O3
- Molecular Weight:130.1
113259-78-2
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84210-26-4
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Yield:84210-26-4 81%
Reaction Conditions:
with ethyloxirane;water at 0 - 20; for 1 h;Product distribution / selectivity;
Steps:
3.1
(1) After 4.83 g of brominated 1-methylhydantoin obtained in the same manner as in 1) of Example 2 were dissolved in 5 ml of ice-cooled distilled water, 2.6 ml of 1,2-butylene oxide were dropped thereinto. The mixture was stirred at room temperature for 1 hour and, after confirming the disappearance of brominated 1-methylhydantoin by HPLC, the solvent was evaporated in vacuo. After an operation of adding ethyl acetate to the residue and evaporating it in vacuo was repeated for three times, ethyl acetate was added to the precipitated crystals followed by maturing for 1 hour. The crystals were filtered off and dried in vacuo at 40°C to give 2.62 g (yield: 81%) of crude crystals of 5-hydroxy-1-methylhydantoin.
References:
EP1493734,2005,A1 Location in patent:Page 7
615-77-0
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84210-26-4
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298-12-4
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598-50-5
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563-96-2
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100558-37-0
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