ChemicalBook CAS DataBase List O-Mesitylenesulfonylhydroxylamine

O-Mesitylenesulfonylhydroxylamine synthesis

5synthesis methods

Product Name:O-Mesitylenesulfonylhydroxylamine
CAS Number:36016-40-7
Molecular formula:C9H13NO3S
Molecular Weight:215.27

To a solution of 89 g (330 mmol) O-(mesitylsulfonyl)acetohydroxamate (1) in dioxane is added with stirring 30 mL perchloric acid (70%) at 0 °C within 10 min, and then stirred for another 10 min. After adding about 20 mL of the acid, the reaction mixture becomes pasty. The crude reaction mixture is poured into ice water to give a white solid of O-(mesitylsulfonyl)hydroxylamine, which is collected, washed with cold water (500 mL), then with cold petroleum ether (300 mL), and dried by maintaining suction for about 1 h; yield 55-65 g (77-92%).

The product should be stored in a refrigerator below 0 °C. Iodometric titration indicates that O-Mesitylenesulfonylhydroxylamine, thus prepared, contains 20-30% water. It can be used for most applications. Further purification can be achieved by the dissolution of a small amount of diethyl ether at room temperature and precipitation with petroleum ether.

36016-39-4 Synthesis

tert-Butyl (Mesitylsulfonyl)oxycarbaMate

36016-39-4
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36016-40-7
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Yield:36016-40-7 100%

Reaction Conditions:

with trifluoroacetic acid at 0; for 1.5 h;

Steps:

Amino 2,4,6-trimethylbenzenesulfonate

TFA (10 mL) was cooled to ice temperature, then Intermediate] (5.0 g, 15.87 mmol) was added. The reaction mixture was stirred at 0°C for 1.5 h, then poured onto crushed ice. The resulting white-coloured precipitate was filtered off, then washed with water (100 mL) and dried under vacuum, to obtain the title compound (4.1 g, quantitative) as a white solid. This material was taken though to the next step without any purification.0H (400 MHz, CDC13) 6.99 (s, 2H), 5.48 (s, 2H), 2.68 (s, 6H), 2.32 (s, 3H).

References:

WO2015/86502,2015,A1 Location in patent:Page/Page column 81

38202-27-6 Synthesis

38202-27-6
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$6.00/1g

36016-40-7
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References

Ethanimidic acid, N-[[(2,4,6-trimethylphenyl)sulfonyl]oxy]-, ethyl ester, (1E)-

1239506-69-4
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36016-40-7
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References

773-64-8 Synthesis

773-64-8
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$5.00/5g

36016-40-7
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References

Benzenesulfonic acid, 2,4,6-trimethyl-, bis(trimethylsilyl)azanyl ester

58658-55-2
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36016-40-7
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References

O-Mesitylenesulfonylhydroxylamine Related Search:

Sulfanilamide 1,3,5-Trimethoxybenzene Dimethyl sulfone N-Acetylsulfanilyl chloride Mesitylene Mesitylene-2-sulfonyl chloride 6-Hydroxypurine Phthalic anhydride HYDROXYLAMINE Ethyl O-mesitylsulfonylacetohydroxamate

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