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ChemicalBook CAS DataBase List Parathion-methyl
298-00-0

Parathion-methyl synthesis

4synthesis methods
Parathion methyl is synthesised via a two-step process similar to that of parathion ethyl. The first step involves the chlorination of dimethyl dithiophosphoric acid to produce dimethylthiophosphoryl chloride. This intermediate is then reacted with sodium 4-nitrophenolate, the sodium salt of 4-nitrophenol, to form parathion methyl. The reaction typically follows the Schrader synthesis method.
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Yield:-

Reaction Conditions:

Schrader synthesis;

Steps:

6 Example 6. Detoxification and biodegradation of methylparathion (METHAPHOS) under the action of lysine and microorganisms.
A sample OF METHYLPARATHION (O, O-DIMETHYL-O-P- nitrophenylthiophosphate) was obtained by the Schrader method interacting O, O- dimethylchlorothiophosphate with sodium salt of p-nitrophenol and was isolated by crystallization. The 1H and 31P NMR spectra data and melting point 34-36°C corresponded to the literature data.

References:

VECKIS INDUSTRIES LTD.;RZUCIDLO, Eugene WO2004/66726, 2004, A2 Location in patent:Page 12

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