PF-04136309 synthesis
- Product Name:PF-04136309
- CAS Number:857650-90-9
- Molecular formula:C14H16F3N3O2
- Molecular Weight:315.29
![Carbamic acid, [(3S)-1-[[[3-(trifluoromethyl)benzoyl]amino]acetyl]-3-pyrrolidinyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/20180629/GIF/857650-89-6.gif)
857650-89-6
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Yield:-
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20; for 1 h;
Steps:
1.C
N-{2-[(3S)-3-Aminopyrrolidin-1-yl]-2-oxoethyl}-3-(trifluoromethyl)benzamide. The above product (4.2 g) was dissolved in 4 N HCl/dioxane (30 mL). After being stirred for 1 hour at room temperature, the solution was concentrated to provide 4.0 g of the title compound. MS (M+H)+ 316.
References:
US2005/192302,2005,A1 Location in patent:Page/Page column 22
![2-[3-(Trifluoromethyl)benzoyl]aminoacetic acid](/CAS/GIF/17794-48-8.gif)
17794-48-8
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$20.00/100mg
857650-90-9
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2251-65-2
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$10.00/1g
857650-90-9
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