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ChemicalBook CAS DataBase List Phorate
298-02-2

Phorate synthesis

2synthesis methods
The industrial synthesis of phorate typically begins with the preparation of dimethyl dithiophosphoric acid, which is reacted with formaldehyde to form a reactive intermediate. This intermediate then undergoes nucleophilic substitution with ethyl mercaptan (ethanethiol), introducing the ethylthio group and forming the final phosphorodithioate structure. An alternative method involves the condensation of chloromethyl sulphide with sodium dithiophosphate. These reactions are conducted under controlled temperature and pH conditions, often in organic solvents such as toluene or xylene, to ensure high yield and minimise side reactions.
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Yield:-

Reaction Conditions:

with water

References:

Yang et al. [Huaxue Xuebao/Acta Chimica Sinica,1959,vol. 25,p. 402,404,405][Chem.Abstr.,1960,p. 19467] Clark et al. [Journal of Agricultural and Food Chemistry,1955,vol. 3,p. 834,835]

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