ChemicalBook CAS DataBase List Pyrazine, 2-(phenylMethyl)-

Pyrazine, 2-(phenylMethyl)- synthesis

9synthesis methods

Product Name:Pyrazine, 2-(phenylMethyl)-
CAS Number:28217-95-0
Molecular formula:C11H10N2
Molecular Weight:170.21

62673-31-8

21948-70-9

28217-95-0

Example 41 Preparation of Compound 215 Step A - Synthesis of 2-benzylpyrazine: To a solution of 2-methylthiopyrazine (1.26 g, 10 mmol) dissolved in 15 mL of THF was added benzylzinc bromide (0.5 M in THF, 40 mL, 20 mmol) followed by tetrakis(triphenylphosphine)palladium (1.16 g, 1 mmol). The reaction mixture was heated to 60 °C and stirred at this temperature for 2 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (eluent: hexane solution of 15% ethyl acetate) to give 2-benzylpyrazine (0.76 g, 45% yield).

108-86-1 Synthesis

108-86-1
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1251919-99-9
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28217-95-0
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$30.00/100mg

Yield:28217-95-0 95%

Reaction Conditions:

with tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene in 1,3,5-trimethyl-benzene at 150; for 24 h;Inert atmosphere;

References:

Shang, Rui;Yang, Zhi-Wei;Wang, Yan;Zhang, Song-Lin;Liu, Lei [Journal of the American Chemical Society,2010,vol. 132,# 41,p. 14391 - 14393] Location in patent:supporting information; experimental part