ChemicalBook CAS DataBase List Pyrazosulfuron-ethyl

Pyrazosulfuron-ethyl synthesis

2synthesis methods

Product Name:Pyrazosulfuron-ethyl
CAS Number:93697-74-6
Molecular formula:C14H18N6O7S
Molecular Weight:414.39

Pyrazosulfuron-ethyl is commercially produced via a sulfonylurea synthesis starting from ethyl 5-amino-1-methylpyrazole-4-carboxylate, which is sulfonylated with 2-(chlorosulfonyl)benzoic acid ethyl ester under basic conditions to form the sulfonamide. This intermediate is activated with phosgene or triphosgene to generate the sulfonyl isocyanate, which undergoes condensation with 2-amino-4,6-dimethoxypyrimidine to construct the urea bridge. Final cyclisation, hydrolysis, and recrystallisation yield pyrazosulfuron-ethyl.

36315-01-2 Synthesis

36315-01-2
519 suppliers
$18.60/2.5g

4223-09-0
5 suppliers
inquiry

93697-74-6
201 suppliers
$30.00/25mg

Yield:-

Reaction Conditions:

in acetonitrile

Steps:

7 Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-methylpyrazole-5-sulfonamide (Compound No. 835):
The above crude sulfonyl isocyanate (0.98 g) was added to a solution of 0.4 g of 2-amino-4,6-dimethoxy pyrimidine in 20 ml of dry acetonitrile and the mixture was stirred at room temperature. The crystals formed were filtered, washed and dried to obtain 0.8 g of the title compound melting at 170°-172° C.

References:

Nissan Chemical Industries, Ltd. US4954164, 1990, A

FullText

36315-01-2 Synthesis

36315-01-2
519 suppliers
$18.60/2.5g

ethyl 5-(chlorosulfonyl)-1-methyl-1H-pyrazole-4-carboxylate

88398-82-7
7 suppliers
inquiry

93697-74-6
201 suppliers
$30.00/25mg

References

Pyrazosulfuron-ethyl Related Search:

Flazasulfuron 2-(Trifluoromethoxy)aniline acetic acid, triethoxy-, ethyl ester Ethyl formate 2-AMINODIETHYLMALONATE Ethanol Ethyl 3-aminopropanoate hydrochloride Ethyl acetate Pyrimidine 1-Methylpyrazole

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.