Pyridine, 4-(difluoromethyl)- (9CI) synthesis
- Product Name:Pyridine, 4-(difluoromethyl)- (9CI)
- CAS Number:82878-62-4
- Molecular formula:C6H5F2N
- Molecular Weight:129.11
Yield: 54 %Spectr.
Reaction Conditions:
Stage #1:4-bromopyridine hydrochloride with tris-(trimethylsilyl)silane;[4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate;sodium carbonate;4,4'-di-tert-butyl-2,2'-bipyridine in 1,2-dimethoxyethane for 0.25 h;Inert atmosphere;
Stage #2:bromodifluoromethane in 1,2-dimethoxyethane at 30; for 18 h;Sealed tube;Irradiation;Inert atmosphere;
References:
Bacauanu, Vlad;Cardinal, Sébastien;Yamauchi, Motoshi;Kondo, Masaru;Fernández, David F.;Remy, Richard;MacMillan, David W. C. [Angewandte Chemie - International Edition,2018,vol. 57,# 38,p. 12543 - 12548][Angew. Chem.,2018,vol. 130,p. 12723 - 12728,6] Location in patent:supporting information
108-89-4
344 suppliers
$15.00/25mL
82878-59-9
32 suppliers
$163.50/1g
82878-62-4
22 suppliers
$58.00/1g
3796-24-5
197 suppliers
$12.00/1g
82878-59-9
32 suppliers
$163.50/1g
82878-62-4
22 suppliers
$58.00/1g
872-85-5
502 suppliers
$10.00/1g
82878-62-4
22 suppliers
$58.00/1g
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
82878-62-4
22 suppliers
$58.00/1g