ChemicalBook CAS DataBase List (R,R,R)-Aprepitant

(R,R,R)-Aprepitant synthesis

1synthesis methods

Product Name:(R,R,R)-Aprepitant
CAS Number:1148113-53-4
Molecular formula:C23H21F7N4O3
Molecular Weight:534.43

252742-72-6 Synthesis

252742-72-6
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$7.00/250mg

(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine

380499-06-9
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1148113-53-4
72 suppliers
$504.12/5MG

Yield:1148113-53-4 99%

Reaction Conditions:

with potassium carbonate in water;N,N-dimethyl-formamide at 0;

References:

Gangula, Srinivas;Elati, Chandrashekhar R.;Mudunuru, Satish Varma;Nardela, Anitha;Dongamanti, Ashok;Bhattacharya, Apurba;Bandichhor, Rakeshwar [Synthetic Communications,2010,vol. 40,# 15,p. 2254 - 2268] Location in patent:experimental part

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