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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List SODIUM FLUOROACETATE
62-74-8

SODIUM FLUOROACETATE synthesis

3synthesis methods
Sodium monofluoroacetate has historically been produced through a straightforward neutralisation and purification process rather than a complex multi-step synthesis. Industrial manufacturers begin with fluoroacetic acid, which itself is obtained from established fluorination chemistry, and react it with a sodium base, typically sodium hydroxide or sodium carbonate, under controlled conditions to form the sodium salt. The resulting sodium monofluoroacetate solution is then concentrated, crystallised, filtered, and dried to yield a stable technical-grade solid.
459-72-3 Synthesis
Ethyl fluoroacetate

459-72-3
213 suppliers
$10.00/1g

SODIUM FLUOROACETATE

62-74-8
0 suppliers
$50.00/25mg

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Yield:62-74-8 99%

Reaction Conditions:

with sodium hydroxide in ethanol at 0;

Steps:

28.A Step A: Sodium 2-fluoroacetate (28-b)
Ethyl 2-fluoroacetate, 28-a, (107g, lmol) was dissolved in absolute EtOH (1L), cooled to 0°C and NaOH (40g, lmol) in EtOH was added. The reaction was stirred overnight after which petroleum ether was added. The reaction solution was cooled to -20°C and filtered giving 104g of title compound, 28-b, as white solid (yield 99 %)

References:

MERCK SHARP & DOHME CORP.;ZHOU, Changyou;ZOU, Wuxin;HUA, Yuxia;DANG, Qun WO2013/40790, 2013, A1 Location in patent:Page/Page column 87

FullText

Methyl fluoroacetate

453-18-9
0 suppliers
$45.00/2.5g

SODIUM FLUOROACETATE

62-74-8
0 suppliers
$50.00/25mg

References
51-21-8 Synthesis
5-Fluorouracil

51-21-8
861 suppliers
$5.00/5g

50-00-0 Synthesis
Formaldehyde

50-00-0
910 suppliers
$10.00/25g

SODIUM FLUOROACETATE

62-74-8
0 suppliers
$50.00/25mg

57-13-6 Synthesis
Urea

57-13-6
831 suppliers
$5.00/5g

References

SODIUM FLUOROACETATE Related Search:

SODIUM PERFLUOROHEXANOATE 2,2,3,3,4,4,5,5,6,6,7,7-DODECAFLUOROHEPTANOIC ACID, SODIUM SALT Sodium 2,2,3,3-tetrafluoropropionate Fluoroacetic acid Sodium acetate trihydrate 7-CHLORODODECAFLUOROHEPTANOIC ACID, SODIUM SALT