β-t-butylpyrrole synthesis
- Product Name:β-t-butylpyrrole
- CAS Number:7721-49-5
- Molecular formula:C8H13N
- Molecular Weight:123.2
97188-28-8
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Yield:7721-49-5 78.4%
Reaction Conditions:
with ethanol;water;potassium hydroxide for 5 h;Reflux;
Steps:
3 Step 3.
To a solution of 3-(tert-Butyl)-1-(phenylsulfonyl)-1H-pyrrole (6.0 g, 22.8 mmol) in EtOH/H2O (60 mL/60 mL) was added KOH (12.8 g, 228 mmol). The mixture was stirred at reflux for 5 h. Then the solvent was removed under reduced pressure. The residue was taken in water (50 mL). The aqueous solution was extracted with DCM (20 mL x 3). The organic layer was washed with brine, dried Na2SO4, filtered and concentrated. The residue was purified by SGC (PE/EA = 5:1) to give 3-(tert-butyl)-1H-pyrrole (2.20 g, 78.4% yield) as a yellow oil.
References:
WO2021/97057,2021,A1 Location in patent:Page/Page column 418
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