TERT-BUTYL-N-METHYLCARBAMATE synthesis
- Product Name:TERT-BUTYL-N-METHYLCARBAMATE
- CAS Number:16066-84-5
- Molecular formula:C6H13NO2
- Molecular Weight:131.17
24424-99-5
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74-89-5
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16066-84-5
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Yield:16066-84-5 91%
Reaction Conditions:
at 20; for 0.5 h;Green chemistry;
Steps:
General Procedure for the Boc Protection of Amines
General procedure: To (Boc)2O (1.0 mmol), was added an amine (1.0 mmol)and the mixture was stirred at room temperature for the time indicated in Table 1. The progress of the reaction was monitored by TLC. In most cases, the BOC protected product was found to be sufficiently pure and did not require any further purification. In some cases the product was purified by silica gel column chromatography (1:2; EtOAc/ Petrolium ether).All products were characterized by IR, 1H NMR and their physical properties.
References:
Mojtahedi, Mohammad Majid;Niknejad, Nina;Veisi, Hojat [Letters in Organic Chemistry,2013,vol. 10,# 2,p. 121 - 125]
24424-99-5
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16066-84-5
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