Topiramate synthesis
- Product Name:Topiramate
- CAS Number:97240-79-4
- Molecular formula:C12H21NO8S
- Molecular Weight:339.36
150609-95-3
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97240-79-4
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Yield:97240-79-4 96.7%
Reaction Conditions:
with ammonia in tetrahydrofuran;hexane at 20; for 3 h;Solvent;Temperature;
Steps:
4-6; 7.2; 8.2; 1.3; 2.2; 3.2; 4.2; 5 Embodiment 4TopiramatePreparation
Weigh 17.3 g of 2,3: 4,5-bis-O- (1-methylethylene) -β-D-fructopyranosyl chlorosulfonate Form A prepared in Example 1 in 300 mL of mixed solvent (Tetrahydrofuran: n-hexane = 20: 80), pass in ammonia gas, react at room temperature for 3h, filter, and concentrate under reduced pressure to about 40mL of the remaining filtrate.Cool to -5 0 to crystallize, filter and dry to obtain 15.8g of white solid (ie: topiramate),Yield: 96.7%, HPLC purity: 99.93%;2,3: 4,5-bis-O- (1-methylethylene) -β-D-fructofuranose: 0.02%; condensate: 0.03%.
References:
CN110655542,2020,A Location in patent:Paragraph 0057-0062; 0063; 0066-0068; 0071; 0072; 0078; 0079
20880-92-6
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97240-79-4
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106881-35-0
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![β-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, [2-(methoxycarbonyl)benzoyl]sulfamate (9CI)](/CAS/20210305/GIF/627538-01-6.gif)
627538-01-6
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97240-79-4
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