| Identification | Back Directory | [Name]
9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- | [CAS]
1000999-96-1 | [Synonyms]
PU-HZ151
Icapamespib
Icapamespib (Synonyms: PU-HZ151)
9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- | [Molecular Formula]
C19H23IN6O2S | [MOL File]
1000999-96-1.mol | [Molecular Weight]
526.39 |
| Chemical Properties | Back Directory | [Boiling point ]
648.4±65.0 °C(Predicted) | [density ]
1.76±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
9.76±0.19(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5?nM. Icapamespib is able to cross blood-brain barrier[1]. | [References]
[1] Bolaender A, et al. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun. 2021;12(1):4669. Published 2021 Aug 3. DOI:10.1038/s41467-021-24821-2 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|