| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydro xy-6,8-bis(3-methyl-2-butenyl)-, (S)- | [CAS]
99119-72-9 | [Synonyms]
Kushenol E
flemiphilippinin D
(2S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydro xy-6,8-bis(3-methyl-2-butenyl)-, (S)-
4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)-,(2S)-
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydro xy-6,8-bis(3-methyl-2-butenyl)-, (S)- USP/EP/BP | [Molecular Formula]
C25H28O6 | [MDL Number]
MFCD31557317 | [MOL File]
99119-72-9.mol | [Molecular Weight]
424.49 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture and light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Cryst. | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the creeping Ficus microcarpa F. philippinensis. | [Uses]
Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7?μM and a Ki of 9.5?μM, has anti-tumor activity[1]. | [target]
NF-kB | ROS | [References]
[1] Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488. DOI:10.1080/14756366.2019.1640218 |
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